PASS syndrome is a rare inflammatory disease characterized by a chronic-relapsing course of pyoderma gangrenosum, acne vulgaris, hidradenitis suppurativa and ankylosing spondylitis.

  • Specific challenges associated with the recognition of the condition

Clinical features may help to make a diagnosis.

  • Specific challenges associated with the diagnosis

No genetic test widely available yet. Mutations have not been detected in all cases.

  • Specific challenges associated with the treatment

No drug registered. No clinical studies performed.

  • Specific challenges associated with care of these patients over their lifespan – Quality of life issues – Gaps accross the care

Skin scarring due to severe acne, pyoderma gangraenosum and hidradenitis suppurativa / acne inversa is prominent.


Incidence : unknown

Prevalence : unknown

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