Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions affecingt the gastrointestinal tract and the central nervous system (CNS) are potentially lethal. Lungs and eyes may also be involved.
- Specific challenges associated with the recognition of the condition
Clinical diagnosis through characteristic skin lesions. No biomarker available.
- Specific challenges associated with the diagnosis
The rarity of the disease leads to limited expertise world wide.
- Specific challenges associated with the treatment
No drug registered. No therapeutic studies performed.
- Specific challenges associated with care of these patients over their lifespan – Quality of life issues – Gaps accross the care
Chronic, usually progressive disease. A few expert centers exist world wide, the patients have to travel internationally for confirmation of diagnosis. International expert network involving established.
Incidence : unknown
Prevalence : <1 / 1 000 000