Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions affecingt the gastrointestinal tract and the central nervous system (CNS) are potentially lethal. Lungs and eyes may also be involved.

  • Specific challenges associated with the recognition of the condition

Clinical diagnosis through characteristic skin lesions. No biomarker available.

  • Specific challenges associated with the diagnosis

The rarity of the disease leads to limited expertise world wide.

  • Specific challenges associated with the treatment

No drug registered. No therapeutic studies performed.

  • Specific challenges associated with care of these patients over their lifespan – Quality of life issues – Gaps accross the care

Chronic, usually progressive disease. A few expert centers exist world wide, the patients have to travel internationally for confirmation of diagnosis. International expert network involving established.


Incidence : unknown

Prevalence : <1 / 1 000 000