Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions affecingt the gastrointestinal tract and the central nervous system (CNS) are potentially lethal. Lungs and eyes may also be involved.

  • Specific challenges associated with the recognition of the condition

Clinical diagnosis through characteristic skin lesions. No biomarker available.

  • Specific challenges associated with the diagnosis

The rarity of the disease leads to limited expertise world wide.

  • Specific challenges associated with the treatment

No drug registered. No therapeutic studies performed.

  • Specific challenges associated with care of these patients over their lifespan – Quality of life issues – Gaps accross the care

Chronic, usually progressive disease. A few expert centers exist world wide, the patients have to travel internationally for confirmation of diagnosis. International expert network involving established.


Incidence : unknown

Prevalence : <1 / 1 000 000

Let's hear from you!

We are constantly working to improve the website and its services. As such, we would greatly appreciate if you could fill this short survey (copy and paste link):